Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death
نویسندگان
چکیده
منابع مشابه
Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death
Nuclear receptor coactivators (NCOAs) function as coactivators for nuclear receptors as well as several other transcription factors and potentiate their transcriptional activity. NCOAs play an important role in biology of hormone-dependent and -independent cancers. MCB-613 is a recently described, small molecule stimulator of NCOAs and anti-neoplastic compound that leads to the death of tumour ...
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A mutation in the nuclear orphan receptor RORa results in a severe impairment of cerebellar development by unknown mechanisms. We have shown previously that RORa contains a strong constitutive activation domain in its C terminus. We therefore searched for mammalian RORa coactivators using the minimal activation domain as bait in a two-hybrid screen. Several known and putative coactivators were ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2018
ISSN: 1949-2553
DOI: 10.18632/oncotarget.24451